Dosing Recommendations

Dosing Recommendations

Over 75% of individuals have genetic variations that affect how drugs are metabolized. PHS partner labs offer customized reports that review a patient’s genetic variants and current list of medications, and offer analysis of risk and/or recommendations for alternative therapies and dosages.

Results are available through a secure online portal. Patients will receive their results on a card that can be shared with other prescribing providers who may participate in care. Because the results are valid for the patient’s lifetime, PGx testing will be an important component of future medication reconciliation.

Medication Therapy Management and PGx Testing

Most of the diseases for which patients seek physician advice are treated by medications that are metabolized by a gene within the cytochrome P450. Drugs used to treat diseases including diabetes, heart disease, hypertension, depression, anxiety, GERD, and chronic pain are metabolized by frequently studied genes CYP2C9, CYP2C19, and CYP2D6. When these diseases are concomitant, risk of ADE grows as the number of medications prescribed to treat them grows.

PGx testing, as a component of medication therapy management, can reduce risk by predicting drug response and alerting prescribers to potential for toxicity or drug-drug interactions. Additionally, testing can address patient non-compliance with prescribed medication therapy by reducing the potential for side effects and increasing the patient confidence that the drug will perform as indicated.

Pharmacogenomics and Drug Metabolism